Journal article
Decreased muscarinic receptor binding in the frontal cortex of bipolar disorder and major depressive disorder subjects
AS Gibbons, E Scarr, C McLean, S Sundram, B Dean
Journal of Affective Disorders | Published : 2009
Abstract
Background: Dysfunction of the cholinergic muscarinic receptors has been implicated in the pathology of bipolar disorder and major depressive disorder. However, there is conflicting evidence regarding the association between individual muscarinic receptors and the two disorders. Methods: We used the muscarinic receptor selective radioligands [3H]pirenzepine, [3H]AFDX-384 and [3H]4-DAMP to measure the levels of muscarinic1 (CHRM1) and muscarinic4 (CHRM4) receptors, muscarinic2 (CHRM2) and muscarinic4 (CHRM4) receptors and muscarinic3 (CHRM3) receptor, respectively. Radioligand binding was measured in Brodmann's area (BA) 10 of the rostral prefrontal cortex, BA 46 of the dorsolateral prefronta..
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Grants
Awarded by National Institutes of Health
Funding Acknowledgements
This study was supported in part by grants-in-aid from the National Health and Medical Research Council (Project Grant no. 350344), The Rebecca L Cooper Medical Research Foundation and the Wood's Family Research Program. The study was supported by the funding grants; NIH RO1 MH069696-01 and NHMRC project grant 3503441. Brian Dean is a NHMRC Senior Research Follow (400016) and Elizabeth Scarr is the Royce Abbey Postdoctoral Fellow (Australian Rotary Health Research Fund). The funding bodies had not further role in study design, in the collection, analysis or interpretation of the data, in the writing of the report or in the decision to Submit the manuscript for publication.